People on Ozempic say they are pooping in their bed due to a symptom that affects up to 30% of users.

The hit weight-loss drugs Ozempic and Wegovy are getting rave reviews among influencers, celebrities, and slimmers, but some users aren’t so lucky.

A growing number of patients are detailing embarrassing and debilitating stomach and bowel symptoms, from severe constipation to loss of bowel control.

The issues have become so common that a Reddit group with over 30,000 members has been created where users share their most embarrassing stories.

One user wrote in one thread: ‘I literally shit myself in my sleep. That is first. It’s been a rough few days of diarrhea after my first injection of semaglutide.’ Meanwhile, an anonymous 43-year-old man who took Wegovy said: “I feel VERY ashamed to be an adult who soiled my pants!”

The drugs slow down the digestive process, making people feel full for longer periods of time. This can lead to constipation, however it can also signal the brain that the stomach contents need to be emptied sooner. This results in diarrhea.

Another user on the same thread was on his way to a birthday dinner and said, “I ended up biting my pants probably 15 minutes later.”

‘Wegovy gave me constant gas that sometimes tricked me into explosive diarrhea. What a nightmare.’

Ozempic and Wegovy use semaglutide, which suppresses appetite and causes weight loss.

The first was approved for type 2 diabetes in 2017. A reformulated version was approved under the Wegovy name in 2021.

The drug is a GLP-1 receptor, which activates hormones in the brain that keep the stomach full and tell the body to stop eating and avoid cravings.

Dr. Daniel Rosen, a weight loss physician, detailed the connection to diarrhea and other symptoms on TikTok.

Dr. Daniel Rosen, a weight-loss physician, explained on TikTok that drugs like Ozempic and Wegovy trick the brain into thinking that food has already reached the end of the intestines, suppressing hunger and making the body need empty its contents faster.

Wegovy works by activating the body to produce a hormone called glucagon-like peptide 1 that is released naturally from the intestines after meals.

“When you eat a large meal, there’s something called the gastrocolic reflex, where stretching in the upper part of the stomach alerts the end of the colon and rectum to empty,” Dr. Rosen said in a video.

This can make you feel like it’s time to go to the bathroom.

GLP-1 drugs trigger a reflex called ileal rupture, which involves the end of the intestines, the ileum, and tells the stomach to stop accepting food. This suppresses hunger.

“GLP-1 drugs trick your brain into thinking that the food has reached the end of the intestines,” Dr. Rosen said.

This could cause the colon to empty food faster, leading to diarrhea.

TikTokers have also complained of gastrointestinal issues.

an user posted two videos about a number of digestive complaints she had since starting Wegovy, including cramps, constipation, and diarrhea.

Another user, who takes Ozempic, said in a video that he experienced cramps, vomiting and ‘sulphur burps’, which smell like rotten eggs.

The long-term results of these drugs are largely unknown, although digestive discomfort is among the most common side effects.

Clinical trials show that 30 percent of patients experience diarrhea with Wegovy, compared to 16 percent with placebo, depending on the drug. prescription information.

Common side effects of Ozempic include constipation, diarrhea, nausea, vomiting and abdominal pain, according to the drug label.

In 2022, more than five million recipes for Ozempic, Mounjaro, Rybelsus (for another Novo drug that uses semaglutide), or Wegovy were written for weight control.

This compares to just over 230,000 in 2019, an increase of more than 2,000% in three years.

Doctors in the US are writing more than 100,000 prescriptions a week for Wegovy, the maker of the drug Novo My dear.